Department of Senological, Gynecological, Plastic and Reconstructive Surgery - Paris Professor Fabrice Lecuru - Institut Curie
  • Facteur de risque du cancer du sein

    The most effective treatment for advanced cancers of the cervix remains concomitant radio-chemotherapy + Brachytherapy

    Mileshkin reported at the last ASCO congress, the results of the OUTBACK study. This trial compared survival after radio-chemotherapy + Brachytherapy with the same treatment followed by 4 additional cycles of chemotherapy.

    Survival was not significantly improved (overall survival and progression-free survival), but treatment toxicity was significantly worsened.

    There is therefore no reason to change our practices, apart from clinical trials. Many studies are currently testing the addition of immunotherapy or other innovative molecules to radio-chemotherapy + Brachytherapy. The COLIBRI study (addition of 2 immunotherapy molecules) is currently open at Institut Curie. Another, similar study will begin in the coming weeks.